Detailed Information [109612]
 

Strain Information
DGRC Number 109612
Genotype with FlyBase Link Oregon-R(R)
Genotype Oregon-R(R)
Received Date 4 June 2009
Comments See Drosophila Mutagenicity Test
Original Source Hiroshi Baba, Mitsubishi Tanabe Pharma Corporation
Original Comments This strain was established by Merrell (Minneapolis, MN, USA) as an insecticide-resistant strain derived from an Oregon R line. Since 1952, this strain had been selected for DDT resistance1),2), and the surviving flies proved to carry the RI gene for insecticide resistance on the second(?) chromosome with increased capability of cytochrome P-450 dependent bioactivation of promutagens/procarcinogens. This strain is suited to increase the test sensitivity for Drosophila assays for detecting various mutagens/carcinogens which requires metabolic activation3).

<References>
(1)Dapkus, D. and D.J. Merrell (1977): Chromosomal analysis of DDT-resistance in a long-term selected population of Drosophila melanogaster, Genetics, 87, 685-697. http://www.genetics.org/cgi/content/abstract/87/4/685
(2)Hällström, I., A. Blanck and S. Atuma (1984): Genetic variation in cytochrome P-450 and xenobiotic metabolism in Drosophila melanogaster, Biochemical Pharmacology, 33, 13-20. doi: 10.1016/0006-2952(84)90364-2
(3)Frölich A. and F.E. Würgler (1989): New tester strain with improved bioactivation capacity for the Drosophila wing-spot test, Mutation Research, 216, 179-187. PMID: 2499781

Genus Drosophila
Subgenus Sophophora
Species Group melanogaster
Species Subgroup melanogaster
Species melanogaster
Reference Dapkus D, Merrell DJ.
Chromosomal analysis of DDT-resistance in a long-term selected population of Drosophila melanogaster.
Genetics (1977) 87(4) 685-97 [RRC reference]

Hllstrm I, Blanck A, Atuma S.
Genetic variation in cytochrome P-450 and xenobiotic metabolism in Drosophila melanogaster.
Biochem. Pharmacol. (1984) 33(1) 13-20 [RRC reference]

Frlich A, Wrgler FE.
New tester strains with improved bioactivation capacity for the Drosophila wing-spot test.
Mutat. Res. (1989) 216(3) 179-87 [RRC reference]
Last update 2020-04-03
Research papers using this strain
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Hallstrom I, Blanck A, Atuma S.
Genetic variation in cytochrome P-450 and xenobiotic metabolism in Drosophila melanogaster.
Biochem. Pharmacol. (1984) 33(1) 13-20 [PubMed ID = 6422940] [RRC reference]

Frolich A, Wurgler FE.
New tester strains with improved bioactivation capacity for the Drosophila wing-spot test.
Mutat. Res. (1989) 216(3) 179-87 [PubMed ID = 2499781] [RRC reference]

Dapkus D, Merrell DJ.
Chromosomal analysis of DDT-resistance in a long-term selected population of Drosophila melanogaster.
Genetics (1977) 87(4) 685-97 [PubMed ID = 414959] [RRC reference]
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