Strain Information | |
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DGRC Number | 109611 |
Genotype with FlyBase Link | sc[*] z[1] w[+(TE)] mei-9[a] mei-41[D5] / FM7c; mwh[*] |
Genotype | sc* z1 w+(TE) mei-9a mei-41D5 / FM7c; mwh* |
Received Date | 4 June 2009 |
Chromosome | 1 |
Comments | Bristles are one-half to two-thirds normal length. 6Feb2013 T.O. See Drosophila Mutagenicity Test |
Original Source | Hiroshi Baba, Mitsubishi Tanabe Pharma Corporation |
Original Comments | This strain was established by Inoue of Mitsubishi Chemical Corporation as a tester strain for simultaneous screening of genotoxic, mutagenic and clastogenic activity of chemical compounds. This assay, referred to as a combined assay for the DNA repair test and the wing spot test (somatic mutation and recombination test), is suited for screening mutagenic/carcinogenic activity of chemical compounds 1), 2), 3). The strain carries two types of X chromosome. One is the DNA repair-defective X-chromosome (sc z[1] w[+(TE)] mei-9[a] mei-41[D5]) and the other is the X chromosome balancer ( In(1)FM7 y[31D] sc[8] dm B / (hereafter designated as FM7 / mei-9 mei-41). The X chromosomal genes, mei-9[a] and mei-41[D5], are an excision-repair defective and a post-replication repair defective mutations, respectively. The third chromosome carries multiple wing hair (mwh[*]), a wing-cuticle marker which confers multiple wing hairs in a single cell. With regard to DNA repair capability, the stock consists of the following four types of flies:
<References> |
Genus | Drosophila |
Subgenus | Sophophora |
Species Group | melanogaster |
Species Subgroup | melanogaster |
Species | melanogaster |
Reference | Inoue H, Baba H, Awano K, Yoshikawa K. Genotoxic effect of griseofulvin in somatic cells of Drosophila melanogaster. Mutat Res (1995) 343(4) 229-34 [RRC reference] Graf U, Wurgler FE, Katz AJ, Frei H, Juon H, Hall CB, Kale PG. Somatic mutation and recombination test in Drosophila melanogaster. Environ Mutagen (1984) 6(2) 153-88 [RRC reference] Fujikawa K, Fort FL, Samejima K, Sakamoto Y. Genotoxic potency in Drosophila melanogaster of selected aromatic amines and polycyclic aromatic hydrocarbons as assayed in the DNA repair test. Mutat Res (1993) 290(2) 175-82 [RRC reference] |
Last update | 2024-07-26 |
Research papers using this strain [Please submit your publication] |
Yanagawa A, Tomaru M, Kajiwara A, Nakajima H, Quemener ED, Steyer JP, Mitani T. Impact of 2.45 GHz Microwave Irradiation on the Fruit Fly, Drosophila melanogaster. Insects (2020) 11(9) [PubMed ID = 32899629] [RRC reference] Fujikawa K, Fort FL, Samejima K, Sakamoto Y. Genotoxic potency in Drosophila melanogaster of selected aromatic amines and polycyclic aromatic hydrocarbons as assayed in the DNA repair test. Mutat Res (1993) 290(2) 175-82 [PubMed ID = 7694108] [RRC reference] Inoue H, Baba H, Awano K, Yoshikawa K. Genotoxic effect of griseofulvin in somatic cells of Drosophila melanogaster. Mutat Res (1995) 343(4) 229-34 [PubMed ID = 7623877] [RRC reference] Graf U, Wurgler FE, Katz AJ, Frei H, Juon H, Hall CB, Kale PG. Somatic mutation and recombination test in Drosophila melanogaster. Environ Mutagen (1984) 6(2) 153-88 [PubMed ID = 6423380] [RRC reference] |
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