Strain Information | |
---|---|
DGRC Number | 109612 |
Genotype with FlyBase Link | Oregon-R(R) |
Genotype | Oregon-R(R) |
Received Date | 4 June 2009 |
Comments | See Drosophila Mutagenicity Test |
Original Source | Hiroshi Baba, Mitsubishi Tanabe Pharma Corporation |
Original Comments | This strain was established by Merrell (Minneapolis, MN, USA) as an insecticide-resistant strain derived from an Oregon R line. Since 1952, this strain had been selected for DDT resistance1),2), and the surviving flies proved to carry the RI gene for insecticide resistance on the second(?) chromosome with increased capability of cytochrome P-450 dependent bioactivation of promutagens/procarcinogens. This strain is suited to increase the test sensitivity for Drosophila assays for detecting various mutagens/carcinogens which requires metabolic activation3). <References> |
Genus | Drosophila |
Subgenus | Sophophora |
Species Group | melanogaster |
Species Subgroup | melanogaster |
Species | melanogaster |
Reference | Dapkus D, Merrell DJ. Chromosomal analysis of DDT-resistance in a long-term selected population of Drosophila melanogaster. Genetics (1977) 87(4) 685-97 [RRC reference] Hallstrom I, Blanck A, Atuma S. Genetic variation in cytochrome P-450 and xenobiotic metabolism in Drosophila melanogaster. Biochem Pharmacol (1984) 33(1) 13-20 [RRC reference] Frolich A, Wurgler FE. New tester strains with improved bioactivation capacity for the Drosophila wing-spot test. Mutat Res (1989) 216(3) 179-87 [RRC reference] |
Last update | 2020-04-03 |
Research papers using this strain [Please submit your publication] |
Yanagawa A, Tomaru M, Kajiwara A, Nakajima H, Quemener ED, Steyer JP, Mitani T. Impact of 2.45 GHz Microwave Irradiation on the Fruit Fly, Drosophila melanogaster. Insects (2020) 11(9) [PubMed ID = 32899629] [RRC reference] Hallstrom I, Blanck A, Atuma S. Genetic variation in cytochrome P-450 and xenobiotic metabolism in Drosophila melanogaster. Biochem Pharmacol (1984) 33(1) 13-20 [PubMed ID = 6422940] [RRC reference] Frolich A, Wurgler FE. New tester strains with improved bioactivation capacity for the Drosophila wing-spot test. Mutat Res (1989) 216(3) 179-87 [PubMed ID = 2499781] [RRC reference] Dapkus D, Merrell DJ. Chromosomal analysis of DDT-resistance in a long-term selected population of Drosophila melanogaster. Genetics (1977) 87(4) 685-97 [PubMed ID = 414959] [RRC reference] |
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