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Humanized fly lines

Human protein genes under the control of UAS

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To facilitate functional annotation of human genes and variants, an international collaborative network of fly resource researchers has been making a large collection of UAS-human ORF transgenic flies based on sequence validated full length human cDNAs. They are now available at KYOTO Stock Center or Bloomington Drosophila Stock Center or both. This project is still ongoing.

Reference:
60th Annual Drosophila Research Conference, 2019, Dallas, TX
A large library of UAS-human cDNA constructs and transgenic Drosophila stocks to facilitate translational research.
S. Yamamoto1,2,3, K.H. Wan4, T. Johnson5, H.K. Graves1, V.H. Bhavana1, H. Pan6, D. Bei1, O. Kanca1, S. Jangam1, S.I. Park4, W.W. Fisher4, Y. Takashima4, S. Ravani4, M. Tomaru7, T. Ohsako7, M.F. Wangler1,3,8, C. Warr9, T. Takano-Shimizu7, H.J. Bellen1,2,3,6, S.E. Celniker4
1) Department of Molecular and Human Genetics, Baylor College of Medicine (BCM), Houston, TX;
2) Department of Neuroscience, BCM, Houston, TX;
3) Jan and Dan Jan and Dan Duncan Neurological Research Institute, Texas Childrens Hospital, Houston, TX;
4) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, Berkeley, CA;
5) School of Biological Sciences, Monash University, Melbourne, Australia;
6) Howard Hughes Medical Institute, Houston, TX;
7) KYOTO Stock Center, DGRC, Kyoto Institute of Technology, Kyoto, Japan;
8) Department of Pediatrics, BCM, Houston, TX;
9) School of Medicine, University of Tasmania, Hobart, Australia.


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Last-modified: 11 Oct 2019 (Fri) 07:14:39 (12d)